When looking at the dosage of drugs and chemotherapy patients only two things are looked at. The drug itself and how much is needed.
Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375329/
The "normal" procedure a patient will go through when needing treatment for chemotherapy is the right dosage. This article states that some were just looking at one big thing, the person's body surface area. Then they move to the metabolic rate and then the blood flow. The reason that the size of the body was being used was because the maximum tolerance was scaled to area and the toxic doses were less consistent when body weight was used to normalise it.
Gurney, said that instead of looking at only those thing that they should also be looking at the activity of drug metabolising enzymes and transporters for genetic reasons. Then the impaired organ function due to either disease or prior therapy.
Someone that has had no experience in the medical field, I believe that both theories are valid. That when someone's life depends on the size of the dosage it should not just consider the size of them because the insides are different for everyone. That doesn't mean that the size cannot affect the dosage but it should not alone decide. Do you think it should just be directly correlated to size of the person?
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